Program Description

Water is known to be essential for a wide variety of physiological functions. Recent evidence suggests that water intake above the amount necessary to replace losses may be beneficial for long term health. Specifically, studies have highlighted a relationship between water intake and recurrent kidney stone disease, chronic kidney disease, blood glucose regulation and cardiovascular events.

This session will describe the mechanisms by which total body water is regulated, with a focus on the interactions between vasopressin and the kidney, and explore links between vasopressin, water intake, and disease. Might increased water intake, by way of reducing circulating vasopressin, be a simple and effective public health measure with impacts upon a number of chronic health outcomes? Intake surveys demonstrate that a substantial proportion of the general population does not ingest sufficient water to confer some reduction in disease risk. More specifically, the recommendation to increase daily water intake will be considered in relation to maintaining kidney function in chronic kidney disease patients.

Learning Objectives

At the end of this session, attendees will be able to:

• Describe the role of vasopressinin body water regulation with a focus on kidney physiology and physiopathology.

• Gain insights on the first pilot study to examine the safety, feasibility and quality of life when asking adults with chronic kidney disease to increase their water intake by 1 to 1.5 L daily.

• Describe the links between vasopressin and/or copeptin, water intake, metabolic syndrome and diabetes and the role of AVP in target organ damage.

Agenda

Chair

Lawrence E. Armstrong, PhD, FACSM, University of Connecticut, Storrs, CT

Presentations

Water and kidney physiology and pathology. Nadine Bouby, PhD, Centre de Recherche des Cordeliers, INSERM, France

Increased water intake in chronic kidney disease: The final frontier. William Clark, MD, FRCPC, FACP, FASN, FCAHS, University of Western Ontario, Canada

Vasopressin, from regulator to disease predictor for diabetes and cardiometabolic risk. Olle Melander, MD, PhD, Lund University, Sweden

Vasopressin and Fluid intake: connecting the dots for future research. Isabelle Guelinckx, PhD, Danone Nutricia Research, France

Questions and Answers.